Diverse potential of beta-lactamase inhibitors to induce class I enzymes
نویسندگان
چکیده
منابع مشابه
Diverse potential of beta-lactamase inhibitors to induce class I enzymes.
The ability of various beta-lactamase inhibitors to induce class I beta-lactamases was assessed. Clavulanate was the most active compound, inducing Morganella morganii, Aeromonas caviae, and Enterobacter aerogenes over a broad concentration range and Citrobacter freundii, Pseudomonas aeruginosa, and Serratia marcescens at high concentrations. Disk approximation tests paralleled these results, w...
متن کاملIn vitro susceptibilities of Capnocytophaga isolates to beta-lactam antibiotics and beta-lactamase inhibitors.
The susceptibilities of 43 pharyngeal isolates of Capnocytophaga to beta-lactam antibiotics, alone or in combination with beta-lactamase inhibitors, were tested by an agar dilution method. The 34 beta-lactamase-positive strains were highly resistant to beta-lactams, but the intrinsic activities of clavulanate, tazobactam, and sulbactam against Capnocytophaga, even beta-lactamase producers, indi...
متن کاملSynergistic activity of piperacillin in combination with beta-lactamase inhibitors.
Clavulanic acid and a penicillanic acid sulfone, when combined individually with piperacillin, synergistically inhibited various Enterobacteriaceae, Staphylococcus aureus, and Bacteroides fragilis. Clavulanic acid and piperacillin synergistically inhibited 91 of 170 (55%) isolates tested. Synergy was most often found against piperacillin-resistant bacteria: 65 of 69 isolates (94%). Although the...
متن کاملDocking for fragment inhibitors of AmpC beta-lactamase.
Fragment screens for new ligands have had wide success, notwithstanding their constraint to libraries of 1,000-10,000 molecules. Larger libraries would be addressable were molecular docking reliable for fragment screens, but this has not been widely accepted. To investigate docking's ability to prioritize fragments, a library of >137,000 such molecules were docked against the structure of beta-...
متن کامل716Risk Factors for Resistance to Beta-lactam/Beta-lactamase Inhibitors and Carbapenems in Bacteroides spp. Bacteremia
and Carbapenems in Bacteroides spp. Bacteremia Janessa Smith, PharmD; Edina Avdic, MBA, PharmD, BCPS AQ-ID; Pranita D. Tamma, MD, MHS; Long Zhang, MHS; Sara Cosgrove, MD, MS, FIDSA, FSHEA; Department of Pharmacy, Johns Hopkins Hospital, Baltimore, MD; Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1990
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.34.1.156